sc 79 Search Results


sc79  (TargetMol)
94
TargetMol sc79
MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), <t>SC79</t> (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
Sc79, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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akt activator sc79  (Tocris)
94
Tocris akt activator sc79
MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), <t>SC79</t> (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
Akt Activator Sc79, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse monoclonal anti meca 79 antibodies  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology mouse monoclonal anti meca 79 antibodies
MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), <t>SC79</t> (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
Mouse Monoclonal Anti Meca 79 Antibodies, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti akap79 santa cruz biotechnology  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology mouse anti akap79 santa cruz biotechnology
MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), <t>SC79</t> (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
Mouse Anti Akap79 Santa Cruz Biotechnology, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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h 1 benzopyran 4 acetic acid ethyl ester  (Tocris)
93
Tocris h 1 benzopyran 4 acetic acid ethyl ester
SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with <t>SC79</t> group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).
H 1 Benzopyran 4 Acetic Acid Ethyl Ester, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human akap79 specific sirna  (Santa Cruz Biotechnology)
85
Santa Cruz Biotechnology human akap79 specific sirna
SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with <t>SC79</t> group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).
Human Akap79 Specific Sirna, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sc-79  (Merck & Co)
90
Merck & Co sc-79
SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with <t>SC79</t> group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).
Sc 79, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sc79  (MedChemExpress)
96
MedChemExpress sc79
SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with <t>SC79</t> group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).
Sc79, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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enoxaparind (3) 2 mg/kg sc 0.74 ± 0.43* (62) 0.38 ± 0.39* (79) na 6.3 ± 5.0*  (Sanofi)
90
Sanofi enoxaparind (3) 2 mg/kg sc 0.74 ± 0.43* (62) 0.38 ± 0.39* (79) na 6.3 ± 5.0*
SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with <t>SC79</t> group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).
Enoxaparind (3) 2 Mg/Kg Sc 0.74 ± 0.43* (62) 0.38 ± 0.39* (79) Na 6.3 ± 5.0*, supplied by Sanofi, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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enoxaparind (3) 2 mg/kg sc 0.74 ± 0.43* (62) 0.38 ± 0.39* (79) na 6.3 ± 5.0* - by Bioz Stars, 2026-03
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Image Search Results


MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), SC79 (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Journal: Drug Design, Development and Therapy

Article Title: MLN4924 Suppresses Acute Myeloid Leukemia Progression by LINC01128-Driven Epigenetic Reactivation of TRIM58

doi: 10.2147/DDDT.S541720

Figure Lengend Snippet: MLN4924 promotes apoptosis through the TRIM58/AKT/BAX axis. ( A ) Western blot analysis of AKT pathway proteins, BCL-2, and BAX in TRIM58-overexpressing MOLM13 cells. ( B ) RT-qPCR quantification of TRIM58 expression in each group. ( C ) Protein expression levels of AKT, p-AKT and TRIM58 in each group were analyzed by Western blot. ( D ) Cell viability was measured at 450 nm using the CCK-8 assay across experimental groups. ( E and F ) Apoptosis assessment by flow cytometry in each group. ( G and H ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), SC79 (5 μM), and MLN4924 + SC79. ( I and J ) Flow cytometry analysis of apoptosis in MOLM13 cells treated with DMSO, MLN4924 (0.3 μM), BIP-V5 (10 μM), and MLN4924 + BIP-V5. Data are shown as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Article Snippet: MOLM13 cells were treated with 5 μM SC79 (TargetMol, Shanghai, China) and 10 μM BIP-V5 (TargetMol, Shanghai, China), respectively.

Techniques: Western Blot, Quantitative RT-PCR, Expressing, CCK-8 Assay, Flow Cytometry

SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with SC79 group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).

Journal: Channels

Article Title: Novel benzoylurea derivative decreases TRPM7 channel function and inhibits cancer cells migration

doi: 10.1080/19336950.2024.2396339

Figure Lengend Snippet: SUD inhibits TRPM7 expression through PI3K/Akt signaling pathway. (a) Effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in MCF-7 cells examined by qPCR. (b) effects of different concentrations SUD on the AKT1 and PI3K mRNA expression in BGC-823 cells examined by qPCR. ***, **** denote significant difference with control group, p <0.001 and p <0.0001, ordinary one-way ANOVA test. (c) Western blot analysis of the relative levels of TRPM7 in MCF-7 cells. (d) Western blot analysis of the relative levels of TRPM7 in BGC-823 cells. *, ***, **** denote significant difference with control group. p <0.05, p <0.001 and p <0.0001, ordinary one-way ANOVA test. ##, and ### denote significant differences with SC79 group. p <0.01 and p <0.001, unpaired t-test. (e, f) correlation between the expression of AKT1 and TRPM7 in breast cancer patients(e) and gastric cancer patients(f). The units in the x, y axis is FPKM (fragments per kilobase of exon model per million mapped fragments).

Article Snippet: SUD was synthesized in-house by the Department of Pharmaceutical Chemistry, Hebei Medical University; 2-Amino- 6-chloro- α- cyano-3- (ethoxycarbonyl)- 4 H–1- benzopyran-4-acetic Acid Ethyl Ester (SC79) was acquired from Tocris Biosciences (USA) and used at a final concentration of 4 μg/mL.

Techniques: Expressing, Control, Western Blot